Derivation of iPS cell line (ICGi032-A) from a patient affected with fragile X syndrome

M M Gridina; E M Shitik; N A Lemskaya; J M Minina; I V Grishchenko; A A Dolskiy; A R Shorina; Y V Maksimova; D V Yudkin

doi:10.1016/j.scr.2021.102615

Derivation of iPS cell line (ICGi032-A) from a patient affected with fragile X syndrome

Stem Cell Res. 2021 Dec:57:102615. doi: 10.1016/j.scr.2021.102615. Epub 2021 Nov 29.

Authors

M M Gridina¹, E M Shitik², N A Lemskaya³, J M Minina¹, I V Grishchenko², A A Dolskiy², A R Shorina⁴, Y V Maksimova⁵, D V Yudkin²

Affiliations

¹ Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia.
² State Research Center of Virology and Biotechnology "Vector", Federal Service for Surveillance on Consumer Rights Protection and Human Well-being (FBRI SRC VB "Vector", Rospotrebnadzor), Koltsovo, Novosibirsk Region, Russia.
³ Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk, Russia.
⁴ SBIH Novosibirsk Municipal Clinical Hospital №1, Novosibirsk, Russia.
⁵ SBIH Novosibirsk Municipal Clinical Hospital №1, Novosibirsk, Russia; Novosibirsk State Medical University, Novosibirsk, Russia.

PMID: 34864218
DOI: 10.1016/j.scr.2021.102615

Abstract

Trinucleotide repeat expansion diseases such as fragile X syndrome are of great interest to study since the mechanism of its development is still unknown. IPS cell lines are some of the most convenient models for studying. The ICGi032-A iPS cell line was obtained from the peripheral blood mononuclear cells of the patient affected with fragile X syndrome. ICGi032-A iPS cell line have a normal karyotype, expression of pluripotency markers and can differentiate in vitro into the cells of three germ layers.