Reduced urinary angiotensinogen excretion in preeclampsia

Abstract

Objective: This study evaluated urinary angiotensinogen in preeclampsia.

Methods: Normal pregnant (n = 57) and preeclamptic patients (n = 31); Normal pregnant (n = 10) and preeclamptic rats (n = 10) were studied. Urinary angiotensinogen and plasma angiotensin II were assayed by enzyme-linked immunosorbent assay (ELISA).

Results: Urinary angiotensinogen in preeclampsia patients (2.0 ± 1.1 ng/mg creatinine) was suppressed (*p < 0.05) compared to normal pregnant (2.7 ± 1.5 ng/mg creatinine). Plasma angiotensin II in preeclampsia patients (preeclampsia: 36.2 ± 7; normal pregnant: 48.1 ± 5 fmol/mL) was lower. The similar result was observed in preeclampsia rat model.

Conclusions: The reduced urinary excretion of angiotensinogen was both in human preeclampsia patients and rat model of preeclampsia.

Keywords: Angiotensin II; Preeclampsia; RAS; Rat model; Urinary angiotensinogen.