Disordered and dead, but in good company: How a catalytically inactive UTX retains its function

Heankel Cantu Oliveros; Benjamin R Sabari

doi:10.1016/j.molcel.2021.10.021

Disordered and dead, but in good company: How a catalytically inactive UTX retains its function

Mol Cell. 2021 Nov 18;81(22):4577-4578. doi: 10.1016/j.molcel.2021.10.021.

Authors

Heankel Cantu Oliveros¹, Benjamin R Sabari²

Affiliations

¹ Laboratory of Nuclear Organization, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA; Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA.
² Laboratory of Nuclear Organization, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA; Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA. Electronic address: benjamin.sabari@utsouthwestern.edu.

PMID: 34798044
DOI: 10.1016/j.molcel.2021.10.021

Abstract

Shi et al. (2021) demonstrate that tumor-suppressive and developmental functions of UTX require an intrinsically disordered region (IDR) capable of condensate formation. These results provide further evidence for the functional role of IDR-mediated spatial organization in regulating gene expression in development and disease.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gene Expression
Intrinsically Disordered Proteins* / genetics

Substances

Intrinsically Disordered Proteins