Abstract
This letter describes microevolution of a pre-XDR MTB strain isolated from a pulmonary TB patient over an 18-month exposure to BDQ. MDR-TB therapies with BDQ require a functional background regimen to prevent emergence of additional resistance. https://bit.ly/3D05qT9
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology
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Antitubercular Agents / therapeutic use
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Drug Resistance, Multiple, Bacterial / genetics
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Extensively Drug-Resistant Tuberculosis* / drug therapy
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Extensively Drug-Resistant Tuberculosis* / genetics
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Humans
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Microbial Sensitivity Tests
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Mutation
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Mycobacterium tuberculosis* / genetics
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Tuberculosis, Multidrug-Resistant* / drug therapy