Non-coding RNA basis of muscle atrophy

Qi Liu; Jiali Deng; Yan Qiu; Juan Gao; Jin Li; Longfei Guan; Hangil Lee; Qiulian Zhou; Junjie Xiao

doi:10.1016/j.omtn.2021.10.010

Non-coding RNA basis of muscle atrophy

Mol Ther Nucleic Acids. 2021 Oct 19:26:1066-1078. doi: 10.1016/j.omtn.2021.10.010. eCollection 2021 Dec 3.

Authors

Qi Liu^{1

2}, Jiali Deng^{1

2}, Yan Qiu^{1

2}, Juan Gao^{1

2}, Jin Li^{1

2}, Longfei Guan³, Hangil Lee⁴, Qiulian Zhou^{1

2}, Junjie Xiao^{1

2}

Affiliations

¹ Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.
² Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai 200444, China.
³ China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China.
⁴ Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Abstract

Muscle atrophy is a common complication of many chronic diseases including heart failure, cancer cachexia, aging, etc. Unhealthy habits and usage of hormones such as dexamethasone can also lead to muscle atrophy. However, the underlying mechanisms of muscle atrophy are not completely understood. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), play vital roles in muscle atrophy. This review mainly discusses the regulation of ncRNAs in muscle atrophy induced by various factors such as heart failure, cancer cachexia, aging, chronic obstructive pulmonary disease (COPD), peripheral nerve injury (PNI), chronic kidney disease (CKD), unhealthy habits, and usage of hormones; highlights the findings of ncRNAs as common regulators in multiple types of muscle atrophy; and summarizes current therapies and underlying mechanisms for muscle atrophy. This review will deepen the understanding of skeletal muscle biology and provide new strategies and insights into gene therapy for muscle atrophy.

Keywords: aging; heart failure; lncRNA; microRNA; muscle atrophy; non-coding RNA.

Publication types

Review