Master protocol trial design for technical feasibility of MR-guided radiotherapy

Alice Couwenberg; Uulke van der Heide; Tomas Janssen; Baukelien van Triest; Peter Remeijer; Corrie Marijnen; Jan-Jakob Sonke; Marlies Nowee

doi:10.1016/j.radonc.2021.11.009

Master protocol trial design for technical feasibility of MR-guided radiotherapy

Radiother Oncol. 2022 Jan:166:33-36. doi: 10.1016/j.radonc.2021.11.009. Epub 2021 Nov 14.

Authors

Alice Couwenberg¹, Uulke van der Heide², Tomas Janssen², Baukelien van Triest², Peter Remeijer², Corrie Marijnen², Jan-Jakob Sonke², Marlies Nowee²

Affiliations

¹ Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: a.couwenberg@nki.nl.
² Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

PMID: 34785244
DOI: 10.1016/j.radonc.2021.11.009

Abstract

The master protocol trial design aims to increase efficiency in terms of trial infrastructure and protocol administration which may accelerate development of (technical) innovations in radiation oncology. A master protocol to study feasibility of techniques/software for MR-guided adaptive radiotherapy with the MR-Linac is described and discussed.

Keywords: Feasibility; MR-Linac; MR-guided radiotherapy; Master protocol trial; Radiotherapy; Study design.

MeSH terms

Clinical Trials as Topic*
Feasibility Studies
Humans
Magnetic Resonance Imaging
Particle Accelerators
Radiation Oncology
Radiotherapy, Image-Guided* / methods
Research Design*