Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy

Neurosci Bull. 2022 Jan;38(1):99-103. doi: 10.1007/s12264-021-00783-9. Epub 2021 Nov 5.

Authors

Xiaodan Zhang¹, Xue Wen¹, Ismael Al-Ramahi^{2

3}, Juan Botas^{2

3}, Boxun Lu¹, Yuhua Fu⁴

Affiliations

¹ School of Life Sciences, Fudan University, Shanghai, 200438, China.
² Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 77030, USA.
³ Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, 77030, USA.
⁴ School of Life Sciences, Fudan University, Shanghai, 200438, China. fuyuhua@fudan.edu.cn.

No abstract available

Publication types

Letter

MeSH terms

Apoptosis / physiology
Autophagy* / physiology
Humans
Huntingtin Protein
Huntington Disease*
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases

Substances

HTT protein, human
Huntingtin Protein
Intracellular Signaling Peptides and Proteins
HIPK3 protein, human
Protein Serine-Threonine Kinases