Abatacept is useful in autoimmune cytopenia with immunopathologic manifestations caused by CTLA-4 defects

Affiliations

• ¹ Pediatric Hemato-Immunology Centre d'Investigation Clinique (CIC) 1401, INSERM Plurithématique CIC (CICP), Bordeaux University Hospital, Bordeaux, France.
• ² Centre de Référence National des Cytopénies Autoimmunes de l'Enfant (CEREVANCE), Bordeaux University Hospital, Bordeaux, France.
• ³ Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), University of Paris, Paris, France.
• ⁴ Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Institut Imagine, Unite Mixte de Recherche (UMR) 1163, INSERM, Paris, France.
• ⁵ Department of Internal Medicine and Infectious Diseases, Bordeaux University Hospital, Bordeaux, France.
• ⁶ Hematology Unit, Necker-Enfants Malades University Hospital, AP-HP, Paris, France.
• ⁷ Department of Internal Medicine, Hospital of Arras, Arras, France.
• ⁸ Department of Internal Medicine, Hospital of Bayonne, Bayonne, France.
• ⁹ Department of Pediatric Hematology, Lille University Hospital, Lille, France.
• ¹⁰ Clinical Immunology Department, Saint Louis University Hospital, AP-HP, Paris, France.
• ¹¹ Pediatric Immuno-Hematology and Rheumatology Department, Necker-Enfants Malades University Hospital, AP-HP, Paris, France.
• ¹² Pediatric Hematology and Oncology Institut, Hospices Civils de Lyon, Lyon, France.
• ¹³ Laboratoire Interuniversitaire de Biologie de la Motricité, EA7424, Team Vascular Biology and Red Blood Cell, University Claude Bernard Lyon 1, University of Lyon, Lyon, France.
• ¹⁴ Pediatric Hematology and Immunology Department, Robert Debré University Hospital, AP-HP, Paris, France; and.
• ¹⁵ Pediatric Oncology Immunology Hematology Unit, Armand-Trousseau University Hospital, AP-HP, Paris, France.