Successful whole lung lavage in a child with pulmonary alveolar proteinosis secondary to hematologic malignancy

Pediatr Pulmonol. 2022 Jan;57(1):308-310. doi: 10.1002/ppul.25718. Epub 2021 Oct 13.

Abstract

Pulmonary alveolar proteinosis (PAP) describes the accumulation of surfactant in the alveolar space. Secondary PAP has been reported in a variety of diseases, and in rare cases has been associated with hematologic malignancy. Treatment for PAP is based on the underlying disease process, and may include whole lung lavage, inhaled or subcutaneous granulocyte-macrophage colony-stimulating factor, or statins. PAP secondary to hematologic malignancy has been reported to demonstrate poor response to whole lung lavage. We report a case of successful treatment of a pediatric patient with acute myeloid leukemia and secondary PAP using whole lung lavage.

Keywords: acute myeloid leukemia; bronchoscopy; pulmonary surfactant.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Bronchoalveolar Lavage
  • Child
  • Hematologic Neoplasms* / complications
  • Hematologic Neoplasms* / therapy
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use
  • Pulmonary Alveolar Proteinosis* / etiology
  • Pulmonary Alveolar Proteinosis* / therapy
  • Pulmonary Surfactants* / therapeutic use

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pulmonary Surfactants