Neurocutaneous melanocytosis-associated malignant melanoma presenting with peritoneal seeding

Pediatr Dermatol. 2021 Sep;38(5):1298-1301. doi: 10.1111/pde.14789. Epub 2021 Aug 31.

Abstract

Neurocutaneous melanocytosis (NCM) is characterized by melanocyte deposition in the leptomeninges and brain parenchyma, primarily occurring in children with large or giant congenital melanocytic nevi (LCMN) or multiple congenital melanocytic nevi. Patients with NCM may develop hydrocephalus and increased intracranial pressure, which can be managed with ventriculoperitoneal (VP) shunting. We present the case of a 16-month-old girl who developed peritoneal carcinomatosis and malignant ascites following VP shunting for hydrocephalus secondary to NCM to increase awareness of this rare, but serious, complication of cerebrospinal fluid diversion.

Keywords: meningeal carcinomatosis; neoplasms malignant; neurocutaneous disorders; nevi-melanocytic; peritoneal carcinomatosis.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Female
  • Humans
  • Infant
  • Melanoma* / complications
  • Melanoma* / diagnosis
  • Melanosis* / diagnosis
  • Melanosis* / etiology
  • Neurocutaneous Syndromes* / complications
  • Neurocutaneous Syndromes* / diagnosis
  • Nevus, Pigmented* / diagnosis
  • Skin Neoplasms* / diagnosis