Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

Qian Luo; Honghu Li; Wei Shan; Cong Wei; Yan Long; Shuyang Cai; Xiangjun Zeng; Xue Li; Yulin Xu; Xiaoxiao Xu; Yi Luo; Pengxu Qian; He Huang

doi:10.1155/2021/9919422

Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

Stem Cells Int. 2021 Aug 11:2021:9919422. doi: 10.1155/2021/9919422. eCollection 2021.

Authors

Qian Luo^{1

2

3

4}, Honghu Li^{1

2

3

4}, Wei Shan^{1

2

3

4}, Cong Wei^{1

2

3

4}, Yan Long^{1

2

3

4}, Shuyang Cai^{1

2

3

4}, Xiangjun Zeng^{1

2

3

4}, Xue Li^{1

2

3

4}, Yulin Xu^{1

2

3

4}, Xiaoxiao Xu^{1

2

3

4}, Yi Luo^{1

2

3

4}, Pengxu Qian^{1

2

3

4

5

6}, He Huang^{1

2

3

4

5}

Affiliations

¹ BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China.
² Institute of Hematology, Zhejiang University, Hangzhou, 310012 Zhejiang, China.
³ Zhejiang Engineering Laboratory for Stem cell and Immunotherapy, Hangzhou, 310012 Zhejiang, China.
⁴ Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, 310012 Zhejiang, China.
⁵ Center of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou 310012, China.
⁶ Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, China.

Abstract

Widely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternative sources for clinic. Existing findings demonstrated that it is feasible to obtain HSCs and certain mature blood lineages from PSCs, except for several issues to be addressed. This short review outlines the technologies used for hematopoietic differentiation in recent years. In addition, the therapeutic value of PSCs as a potential source of various blood cells is also discussed as well as its challenges and directions in future clinical applications.

Publication types

Review