Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography

Andrew Perley; Mehrdad Roustaei; Marcelo Aguilar-Rivera; David C Kunkel; Tzung K Hsiai; Todd P Coleman; Parinaz Abiri

doi:10.1186/s42234-021-00074-8

Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography

Bioelectron Med. 2021 Aug 24;7(1):12. doi: 10.1186/s42234-021-00074-8.

Authors

Andrew Perley¹, Mehrdad Roustaei², Marcelo Aguilar-Rivera¹, David C Kunkel³, Tzung K Hsiai^{2

4}, Todd P Coleman¹, Parinaz Abiri^{5

6}

Affiliations

¹ Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
² Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
³ Division of Gastroenterology, University of California, San Diego, La Jolla, CA, 92093, USA.
⁴ Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
⁵ Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. pabiri@ucla.edu.
⁶ Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. pabiri@ucla.edu.

Abstract

Background: Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical complications and an incomplete understanding of the mechanism by which electrical stimulation affects physiology.

Methods: A leadless inductively-powered pacemaker was implanted on the gastric serosa in an anesthetized pig. Wireless pacing was performed at transmitter-to-receiver distances up to 20 mm, frequency of 0.05 Hz, and pulse width of 400 ms. Electrogastrogram (EGG) recordings using cutaneous and serosal electrode arrays were analyzed to compute spectral and spatial statistical parameters associated with the slow wave.

Results: Our data demonstrated evident change in EGG signal patterns upon initiation of pacing. A buffer period was noted before a pattern of entrainment appeared with consistent and low variability in slow wave direction. A spectral power increase in the EGG frequency band during entrainment also suggested that pacing increased strength of the slow wave.

Conclusion: Our preliminary in vivo study using wireless pacing and concurrent EGG recording established the foundations for a minimally invasive approach to understand and optimize the effect of pacing on gastric motor activity as a means to treat conditions of gastric dysmotility.

Keywords: Electrogastrogram; Electrogastrography; Gastric pacemaker; Gastric pacing; Gastroparesis; Wireless electrical stimulation; Wireless pacing.

Abstract

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