Lorlatinib in a Child with ALK-Fusion-Positive High-Grade Glioma

N Engl J Med. 2021 Aug 19;385(8):761-763. doi: 10.1056/NEJMc2101264.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aminopyridines
  • Anaplastic Lymphoma Kinase / antagonists & inhibitors*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery
  • Child, Preschool
  • Combined Modality Therapy
  • Glioma / diagnostic imaging
  • Glioma / drug therapy*
  • Glioma / pathology
  • Glioma / surgery
  • Humans
  • Lactams
  • Lactams, Macrocyclic / therapeutic use*
  • Magnetic Resonance Imaging
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / pathology
  • Pyrazoles
  • Remission Induction

Substances

  • Aminopyridines
  • Lactams
  • Lactams, Macrocyclic
  • Pyrazoles
  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • lorlatinib