Ten Years of EWAS

Siyu Wei; Junxian Tao; Jing Xu; Xingyu Chen; Zhaoyang Wang; Nan Zhang; Lijiao Zuo; Zhe Jia; Haiyan Chen; Hongmei Sun; Yubo Yan; Mingming Zhang; Hongchao Lv; Fanwu Kong; Lian Duan; Ye Ma; Mingzhi Liao; Liangde Xu; Rennan Feng; Guiyou Liu; The Ewas Project; Yongshuai Jiang

doi:10.1002/advs.202100727

Ten Years of EWAS

Adv Sci (Weinh). 2021 Oct;8(20):e2100727. doi: 10.1002/advs.202100727. Epub 2021 Aug 11.

Authors

Siyu Wei^{1

2}, Junxian Tao^{1

2}, Jing Xu^{1

2}, Xingyu Chen¹, Zhaoyang Wang¹, Nan Zhang¹, Lijiao Zuo¹, Zhe Jia¹, Haiyan Chen¹, Hongmei Sun¹, Yubo Yan¹, Mingming Zhang¹, Hongchao Lv¹, Fanwu Kong^{2

3}, Lian Duan^{2

4}, Ye Ma^{1

2}, Mingzhi Liao^{2

5}, Liangde Xu^{2

6}, Rennan Feng^{2

7}, Guiyou Liu^{2

8}, The Ewas Project², Yongshuai Jiang^{1

2}

Affiliations

¹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
² The EWAS Project, Harbin, China.
³ Department of Nephrology, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
⁴ The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
⁵ College of Life Sciences, Northwest A&F University, Yangling, Shanxi, 712100, China.
⁶ School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, China.
⁷ Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, 150081, China.
⁸ Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.

Abstract

Epigenome-wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next-generation, and third-generation sequencing technologies have prepared a high-quality platform for EWAS. Here, the progress of EWAS research is reviewed, its contributions to clinical applications, and mainly describe the achievements of four typical diseases. Finally, the challenges encountered by EWAS and make bold predictions for its future development are presented.

Keywords: DNA methylation; epigenetics; epigenome-wide association study (EWAS).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

CpG Islands / genetics
DNA Methylation / genetics*
Epigenome / genetics*
Genetic Diseases, Inborn / genetics*
Genetic Diseases, Inborn / pathology
Genetic Predisposition to Disease*
Genome-Wide Association Study
Humans
Sequence Analysis

Abstract

Publication types

MeSH terms

Grants and funding