Walsogynes H-O from Walsura chrysogyne

J Nat Med. 2022 Jan;76(1):94-101. doi: 10.1007/s11418-021-01556-4. Epub 2021 Aug 5.

Abstract

Eight new limonoids, walsogynes H-O (1-8) were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H-M (1-6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c']difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc:5,4-b'c']difuran skeleton. Walsogynes H-O (1-8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1 µM, respectively.

Keywords: Antimalarial activity; Limonoids; Walsura chrysogyne.

MeSH terms

  • Antimalarials* / pharmacology
  • Limonins*
  • Magnetic Resonance Spectroscopy
  • Meliaceae*
  • Molecular Structure
  • Plasmodium falciparum

Substances

  • Antimalarials
  • Limonins