Donor-derived gene mutations in sex chromosome loss after stem cell transplantation

Br J Haematol. 2021 Nov;195(3):e142-e146. doi: 10.1111/bjh.17716. Epub 2021 Jul 27.

Authors

Hiroto Adachi¹, Daichi Sadato^{2

3}, Takashi Toya¹, Chizuko Hirama^{2

3}, Kyoko Haraguchi⁴, Junichi Mukae¹, Naoki Shingai¹, Hiroaki Shimizu¹, Yuho Najima¹, Takeshi Kobayashi¹, Yoshiki Okuyama⁴, Keisuke Oboki³, Hironori Harada^{1

5}, Hisashi Sakamaki¹, Kazuteru Ohashi¹, Yuka Harada², Noriko Doki¹

Affiliations

¹ Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
² Clinical Research Support Center, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
³ Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
⁴ Division of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
⁵ Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy & Life Sciences, Tokyo, Japan.

PMID: 34312849
DOI: 10.1111/bjh.17716

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Allografts
DNA Methyltransferase 3A / genetics
Female
Follow-Up Studies
Hematopoietic Stem Cell Transplantation* / adverse effects
Histone-Lysine N-Methyltransferase / genetics
Humans
In Situ Hybridization, Fluorescence
Male
Mutation*
Myeloid-Lymphoid Leukemia Protein / genetics
Pancytopenia / etiology
Polymorphism, Single Nucleotide
Retrospective Studies
Sex Chromosome Aberrations*
Sex Chromosomes / genetics*
Thrombocytopenia / etiology
Tissue Donors*
Transplantation Chimera / genetics
Tumor Suppressor Protein p53 / genetics
Young Adult

Substances

DNMT3A protein, human
KMT2A protein, human
TP53 protein, human
Tumor Suppressor Protein p53
Myeloid-Lymphoid Leukemia Protein
DNA Methyltransferase 3A
Histone-Lysine N-Methyltransferase