Hepatocarcinogenesis: Radiology-Pathology Correlation

Alice Fung; Krishna P Shanbhogue; Myles T Taffel; Brian T Brinkerhoff; Neil D Theise

doi:10.1016/j.mric.2021.05.007

Hepatocarcinogenesis: Radiology-Pathology Correlation

Magn Reson Imaging Clin N Am. 2021 Aug;29(3):359-374. doi: 10.1016/j.mric.2021.05.007.

Authors

Alice Fung¹, Krishna P Shanbhogue², Myles T Taffel², Brian T Brinkerhoff³, Neil D Theise⁴

Affiliations

¹ Department of Diagnostic Radiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-340, Portland, OR 97239, USA. Electronic address: funga@ohsu.edu.
² Department of Radiology, New York University Grossman School of Medicine, 660 First Avenue, 3rd Floor, New York, NY 10016, USA.
³ Department of Pathology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-113, Portland, OR 97239, USA.
⁴ Department of Pathology, MSB 504A, New York University Grossman School of Medicine, 560 First Avenue, New York, NY 10016, USA.

PMID: 34243923
DOI: 10.1016/j.mric.2021.05.007

Abstract

In the background of chronic liver disease, hepatocellular carcinoma develops via a complex, multistep process called hepatocarcinogenesis. This article reviews the causes contributing to the process. Emphasis is made on the imaging manifestations of the pathologic changes seen at many stages of hepatocarcinogenesis, from regenerative nodules to dysplastic nodules and then to hepatocellular carcinoma.

Keywords: Dysplastic nodule; Hepatocarcinogenesis; Hepatocellular carcinoma; Liver; Liver reporting & data system (LI-RADS).

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular* / diagnostic imaging
Humans
Liver Neoplasms* / diagnostic imaging
Magnetic Resonance Imaging
Radiography
Radiology*