Peptide Mini-Vectors for Gene Delivery

Robert G Cooper; Richard P Harbottle; Holm Schneider; Charles Coutelle; Andrew D Miller

doi:10.1002/(SICI)1521-3773(19990712)38:13/14<1949::AID-ANIE1949>3.0.CO;2-S

Peptide Mini-Vectors for Gene Delivery

Angew Chem Int Ed Engl. 1999 Jul 12;38(13-14):1949-1952. doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<1949::AID-ANIE1949>3.0.CO;2-S.

Authors

Robert G Cooper¹, Richard P Harbottle², Holm Schneider², Charles Coutelle², Andrew D Miller¹

Affiliations

¹ The Imperial College Genetic Therapies Centre Department of Chemistry, Imperial College of Science, Technology & Medicine, South Kensington, London SW7 2AY (UK), Fax: (+44) 171-594-5803.
² Cystic Fibrosis Gene Therapy Research Group, Molecular Genetics Division of Biomedical Sciences, Imperial College School of Medicine (UK).

Abstract

The effective treatment of diseases by gene therapy may be a step nearer with the synthesis of two new peptide-based vectors for the delivery of genes to cells. A combination of two peptides-one containing an Arg-Gly-Asp integrin-binding motif, the other a fusogenic moiety-delivers genes almost as effectively as cationic liposomes.

Keywords: Cations; Drug delivery; Gene technology; Liposomes; Peptides.