Severe antibody-mediated transfusion-related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non-transfused male blood donor

Charlotte Nielsen Agergaard; Thure Mors Haunstrup; Anne-Louise Fjordside; John Baech; Rudi Steffensen; Kaspar René Nielsen

doi:10.1002/ccr3.3818

Severe antibody-mediated transfusion-related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non-transfused male blood donor

Clin Case Rep. 2021 Jun 10;9(6):e03818. doi: 10.1002/ccr3.3818. eCollection 2021 Jun.

Authors

Charlotte Nielsen Agergaard^{1

2}, Thure Mors Haunstrup³, Anne-Louise Fjordside³, John Baech³, Rudi Steffensen³, Kaspar René Nielsen³

Affiliations

¹ Department of Clinical Immunology Odense University Hospital Odense Denmark.
² Department of Clinical Microbiology Vejle Hospital University Hospital of Southern Denmark Vejle Denmark.
³ Department of Clinical Immunology Aalborg University Hospital Aalborg Denmark.

Abstract

Transfusion-Related Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of life-threatening TRALI in an obstetric patient triggered by transfusion from a non-transfused male blood donor. A residual risk of TRALI exist, even in a male-only plasma setting.

Keywords: TRALI; Transfusion; neutrophil antibodies; plasma.

Publication types

Case Reports