1 From the Department of Anaesthesia, Intensive Care and Pain Medicine (MS), Department of Neurosurgery, Justus-Liebig-University, Gießen, Germany (EU); Department of Internal Medicine, Cardiology and Pulmonary Diseases, Wilhelminenspital, Wien, Medical University Vienna and Sigmund Freud University Vienna, Austria (MK), Department of Anaesthesia, Intensive Care and Pain Medicine, RKH Hospital Ludwigsburg, Germany (GG), Division of Anaesthesia, Analgesia, and Intensive Care, Department of Medicine and Surgery - University of Perugia, Italy (ED-R) and Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Germany (KZ).