Sweet Dre-ams about intersectional genetics

John P Woods; R Sathish Srinivasan; Lorin E Olson

doi:10.1016/j.stem.2021.05.005

Sweet Dre-ams about intersectional genetics

Cell Stem Cell. 2021 Jun 3;28(6):989-990. doi: 10.1016/j.stem.2021.05.005.

Authors

John P Woods¹, R Sathish Srinivasan¹, Lorin E Olson²

Affiliations

¹ Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
² Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Electronic address: lorin-olson@omrf.org.

PMID: 34087159
DOI: 10.1016/j.stem.2021.05.005

Abstract

Specific cell targeting with one site-specific recombinase is challenging. In this issue of Cell Stem Cell, Han et al. (2021) released a collection of Dre drivers and demonstrate how two recombinases can be combined to improve the cell specificity of lineage tracing and gene inactivation in mice.

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MeSH terms

Animals
Base Sequence
Cell Movement
Integrases* / metabolism
Mice
Recombinases* / genetics
Recombinases* / metabolism

Substances

Recombinases
Integrases