Dysphagia profiles after primary transoral robotic surgery or radiation for oropharyngeal cancer: A registry analysis

Abstract

Objective: To describe the physiologic swallowing impairments (MBSImP™©) associated with safety/efficiency impairments (DIGEST_safety /DIGEST_efficiency grades) at 3-6 months after transoral robotic surgery (TORS) or radiation therapy (RT).

Study design: Secondary analysis of registry data.

Setting: Single, academic institution.

Methods: Two hundred and fifty-seven patients with HPV+ oropharynx cancer were stratified by primary treatment (75 TORS, 182 RT). Modified barium swallow studies were analyzed at baseline and 3-6 months using MBSImP scores and DIGEST_safety /DIGEST_efficiency grades. DIGEST_safety /DIGEST_efficiency grades and MBSImP were compared groupwise and associations between DIGEST_safety /DIGEST_efficiency grades and MBSImP were explored by ordinal logistic regression. Exploratory analyses were stratified by multimodality treatment.

Results: Neither DIGEST_safety /DIGEST_efficiency differed significantly between groups at baseline or 3-6 months. Laryngeal vestibule closure was impaired more frequently in the RT group (RT: 41% vs. TORS: 27%; p = 0.02) while the TORS group had significantly more pharyngeal contraction impairment (63%; p < 0.001) compared to RT at 3-6 months.

Conclusion: The results suggest a focal injury associated with DIGEST_safety /DIGEST_efficiency post-TORS in contrast to a low-level diffuse physiologic impairment associated with post-RT dysphagia.

Keywords: dysphagia; head and neck cancer; radiation; surgery.