Successful treatment of "accelerated" chronic lymphocytic leukemia with single agent ibrutinib: A report of two cases

Leuk Res Rep. 2021 May 17:15:100247. doi: 10.1016/j.lrr.2021.100247. eCollection 2021.

Abstract

"Accelerated" chronic lymphocytic leukemia/small lymphocytic lymphoma (A-CLL) is a rare histological variant of CLL/SLL, which tends to exhibit an aggressive clinical behavior compared to CLL. Due to the rarity of A-CLL (<1% of all cases), the optimal management remains ill-defined. We report two cases of A-CLL from our institution, in which both relapsed following initial chemoimmunotherapy regimens. Both patients were treated with single agent ibrutinib, a Bruton's tyrosine kinase inhibitor (BTKi), and achieved rapid, deep and durable responses. With the absence of clear guidance on A-CLL treatment, BTKi agents should be considered in the frontline treatment of A-CLL.

Keywords: Accelerated; CLL; Ibrutinib; SLL.

Publication types

  • Case Reports