Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19

Leukemia. 2021 Sep;35(9):2710-2714. doi: 10.1038/s41375-021-01299-x. Epub 2021 May 24.

Giuseppe Gritti¹, Federico Raimondi^{2

3}, Barbara Bottazzi⁴, Diego Ripamonti⁵, Ivano Riva⁶, Francesco Landi^{7

8}, Leonardo Alborghetti⁵, Marco Frigeni⁷, Marianna Damiani^{6

9}, Caterina Micò⁷, Stefano Fagiuoli¹⁰, Ferdinando Luca Lorini⁶, Lucia Gandini^{6

9}, Luca Novelli², Jonathan P Morgan¹¹, Benjamin M J Owens¹¹, Karan J K Kanhai¹¹, Gordana Tonkovic Reljanovic¹², Marco Rizzi⁵, Fabiano Di Marco^{2

13}, Alberto Mantovani^{3

14

15}, Alessandro Rambaldi^{7

16}

¹ Hematology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy. g.gritti@asst-pg23.it.
² Pneumology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.
³ Postgraduate School of Respiratory Medicine, University of Milan, Milan, Italy.
⁴ Humanitas Clinical and Research Center - IRCCS, Milan, Italy.
⁵ Infectious Diseases Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.
⁶ Intensive Care Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.
⁷ Hematology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.
⁸ Postgraduate School of Hematology, University of Milan, Milan, Italy.
⁹ Postgraduate School of Anesthesiology and Intensive Care, University of Milan, Milan, Italy.
¹⁰ Gastroenterology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.
¹¹ EUSA Pharma, Hemel Hempstead, UK.
¹² ErgoMed PLC, Guildford, UK.
¹³ Department of Health Sciences, University of Milan, Milan, Italy.
¹⁴ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹⁵ The William Harvey Research Institute, Queen Mary University of London, London, UK.
¹⁶ Department of Oncology-Hematology, University of Milan, Milan, Italy.

No abstract available

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