Comment on "Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI"

Sci Transl Med. 2021 May 12;13(593):eabd0214. doi: 10.1126/scitranslmed.abd0214.

Authors

Zhilin Luan^{1

2}, Wenhua Ming¹, Cong Zhang¹, Xiaoxiao Huo¹, Feng Zheng¹, Xiaoyan Zhang^{1

2}, Youfei Guan^{3

2}

Affiliations

¹ Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.
² Department of Physiology and Pathophysiology, School of Basic Medical Sciences.
³ Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China. guanyf@dmu.edu.cn.

PMID: 33980573
DOI: 10.1126/scitranslmed.abd0214

Abstract

The nuclear pregnane X receptor may not protect against ischemia/reperfusion-induced acute kidney injury in mice.

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Publication types

Comment

MeSH terms

Acute Kidney Injury*
Animals
Kidney / metabolism
Mice
Mitochondria
Receptors, Cytoplasmic and Nuclear / metabolism
Reperfusion Injury* / metabolism

Substances

Receptors, Cytoplasmic and Nuclear