Molecular Functions of WWOX Potentially Involved in Cancer Development

Karim Taouis; Keltouma Driouch; Rosette Lidereau; François Lallemand

doi:10.3390/cells10051051

Molecular Functions of WWOX Potentially Involved in Cancer Development

Cells. 2021 Apr 29;10(5):1051. doi: 10.3390/cells10051051.

Authors

Karim Taouis¹, Keltouma Driouch¹, Rosette Lidereau¹, François Lallemand¹

Affiliation

¹ Pharmacogenomics Unit, Department of Genetics, Institut Curie, 75005 Paris, France.

Abstract

The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.

Keywords: WWOX; cancers; molecular functions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carcinogenesis / genetics
Carcinogenesis / metabolism*
Cell Death
Gene Expression Regulation, Neoplastic
Genomic Instability
Humans
WW Domain-Containing Oxidoreductase / genetics
WW Domain-Containing Oxidoreductase / metabolism*
Warburg Effect, Oncologic

Substances

WW Domain-Containing Oxidoreductase