The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma

Lauren Fishbein; Jaydira Del Rivero; Tobias Else; James R Howe; Sylvia L Asa; Debbie L Cohen; Patricia L M Dahia; Douglas L Fraker; Karyn A Goodman; Thomas A Hope; Pamela L Kunz; Kimberly Perez; Nancy D Perrier; Daniel A Pryma; Mabel Ryder; Aaron R Sasson; Michael C Soulen; Camilo Jimenez

doi:10.1097/MPA.0000000000001792

The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma

Pancreas. 2021 Apr 1;50(4):469-493. doi: 10.1097/MPA.0000000000001792.

Authors

Lauren Fishbein¹, Jaydira Del Rivero², Tobias Else³, James R Howe⁴, Sylvia L Asa⁵, Debbie L Cohen⁶, Patricia L M Dahia⁷, Douglas L Fraker⁸, Karyn A Goodman⁹, Thomas A Hope¹⁰, Pamela L Kunz¹¹, Kimberly Perez¹², Nancy D Perrier¹³, Daniel A Pryma¹⁴, Mabel Ryder¹⁵, Aaron R Sasson¹⁶, Michael C Soulen¹⁷, Camilo Jimenez¹⁸

Affiliations

¹ From the Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
² Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
³ Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
⁴ Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA.
⁵ Department of Pathology, University Hospitals Cleveland Medical Center and University Health Network, Toronto, Case Western Reserve University, Cleveland, OH.
⁶ Renal Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
⁷ Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX.
⁸ Division of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania and Abramson Cancer Center, Philadelphia, PA.
⁹ Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
¹⁰ Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
¹¹ Division of Oncology, Department of Medicine, Yale School of Medicine, New Haven, CT.
¹² Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
¹³ Division of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
¹⁴ Department of Radiology and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
¹⁵ Endocrine Oncology Tumor Group, Division of Medical Oncology, Mayo Clinic, Rochester, MN.
¹⁶ Division of Surgical Oncology, Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY.
¹⁷ Department of Radiology, University of Pennsylvania, Philadelphia, PA.
¹⁸ Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX.

PMID: 33939658
DOI: 10.1097/MPA.0000000000001792

Abstract

This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the medical management and surveillance of metastatic and unresectable pheochromocytoma and paraganglioma held on October 2 and 3, 2019. The panelists consisted of endocrinologists, medical oncologists, surgeons, radiologists/nuclear medicine physicians, nephrologists, pathologists, and radiation oncologists. The panelists performed a literature review on a series of questions regarding the medical management of metastatic and unresectable pheochromocytoma and paraganglioma as well as questions regarding surveillance after resection. The panelists voted on controversial topics, and final recommendations were sent to all panel members for final approval.

Publication types

Consensus Development Conference
Practice Guideline

MeSH terms

Adrenal Gland Neoplasms / diagnosis
Adrenal Gland Neoplasms / therapy*
Humans
Medical Oncology / methods
Medical Oncology / standards
Neoplasm Metastasis
Neuroendocrine Tumors / diagnosis
Neuroendocrine Tumors / therapy*
North America
Paraganglioma / diagnosis
Paraganglioma / therapy*
Pheochromocytoma / diagnosis
Pheochromocytoma / therapy*
Societies, Medical

Grants and funding

R01 GM114102/GM/NIGMS NIH HHS/United States