High-dose dexamethasone and high-dose metoclopramide versus high-dose dexamethasone and sulpiride in the management of cisplatin-induced emesis

Oncology. 1988;45(4):297-9. doi: 10.1159/000226626.

Abstract

Twenty-eight courses of combination chemotherapy including cisplatin at the dose of 50 mg/m2 were analyzed in this antiemetic randomized double-blind study. The combination of high-dose dexamethasone and high-dose metoclopramide (regimen A) was compared with the combination of high-dose dexamethasone and sulpiride (regimen B). Regimen A was found to be more effective than regimen B when the mean score for intensity of vomiting was presented in only two categories. Four patients (14.3%) treated with regimen A suffered neither from nausea nor from vomiting. No serious side effects were observed.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carcinoma, Squamous Cell / drug therapy
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects*
  • Dexamethasone / administration & dosage
  • Double-Blind Method
  • Drug Evaluation
  • Female
  • Head and Neck Neoplasms / drug therapy
  • Humans
  • Male
  • Metoclopramide / administration & dosage
  • Ovarian Neoplasms / drug therapy
  • Random Allocation
  • Sulpiride / administration & dosage
  • Vomiting / prevention & control*

Substances

  • Sulpiride
  • Dexamethasone
  • Metoclopramide
  • Cisplatin