Abstract
Twenty-eight courses of combination chemotherapy including cisplatin at the dose of 50 mg/m2 were analyzed in this antiemetic randomized double-blind study. The combination of high-dose dexamethasone and high-dose metoclopramide (regimen A) was compared with the combination of high-dose dexamethasone and sulpiride (regimen B). Regimen A was found to be more effective than regimen B when the mean score for intensity of vomiting was presented in only two categories. Four patients (14.3%) treated with regimen A suffered neither from nausea nor from vomiting. No serious side effects were observed.
Publication types
-
Clinical Trial
-
Randomized Controlled Trial
MeSH terms
-
Antineoplastic Combined Chemotherapy Protocols / adverse effects
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Carcinoma, Squamous Cell / drug therapy
-
Cisplatin / administration & dosage
-
Cisplatin / adverse effects*
-
Dexamethasone / administration & dosage
-
Double-Blind Method
-
Drug Evaluation
-
Female
-
Head and Neck Neoplasms / drug therapy
-
Humans
-
Male
-
Metoclopramide / administration & dosage
-
Ovarian Neoplasms / drug therapy
-
Random Allocation
-
Sulpiride / administration & dosage
-
Vomiting / prevention & control*
Substances
-
Sulpiride
-
Dexamethasone
-
Metoclopramide
-
Cisplatin