Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model

Front Endocrinol (Lausanne). 2021 Mar 25:12:627718. doi: 10.3389/fendo.2021.627718. eCollection 2021.

Abstract

Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation in vitro. Local ESW treatment of femur increased bone formation in vivo. Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway.

Keywords: SMAD2; extracorporeal shock wave; osteoblast; osteogenic differentiation; osteoporosis; osteoporosis model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Extracorporeal Shockwave Therapy / methods*
  • Femur / metabolism
  • Femur / physiopathology
  • Osteogenesis / physiology*
  • Osteoporosis / physiopathology
  • Osteoporosis / therapy*
  • Rabbits
  • Smad2 Protein / metabolism

Substances

  • Smad2 Protein