The utilisation of CytB and COI barcodes for the identification of bloodmeals and Culicoides species (Diptera: Ceratopogonidae) reveals a variety of novel wildlife hosts in South Africa

Acta Trop. 2021 Jul:219:105913. doi: 10.1016/j.actatropica.2021.105913. Epub 2021 Apr 5.

Abstract

Biting midges in the genus Culicoides (Diptera; Ceratopogonidae) are vectors of pathogens that can cause diseases of major economic importance in humans and animals. Identifying host ranges of these biting midges might aid in understanding the complex epidemiology of such diseases, often involving reservoir hosts and multiple species. In this study, we aim to identify bloodmeal origin from engorged female Culicoides biting midges. All bloodfed females were opportunistically collected as part of an ongoing surveillance programme using Onderstepoort light traps in two provinces in South Africa. DNA of individuals was extracted and subjected to PCR targeting the cytochrome B (CytB) gene region of mammals and avians as well as cytochrome oxidase I (COI) for species identification. In total, 21 new reference barcodes were generated for C. bedfordi, C imicola, C. leucosticus, C. magnus, and C. pycnostictus. Seventy-four blood meals were identified, originating from 12 mammal and three avian species. COI sequence data performed well for species delimitation and 54 Culicoides specimens were identified with C. imicola the predominant species identified (41.8%). Generally, Culicoides species feed on a variety of hosts and host availability might be an important factor when selecting a host. Culicoides species thus appear to be opportunistic feeders rather than specialists. This implicates Culicoides as transfer vectors and demonstrates possible transmission routes of arboviruses and other pathogens from wildlife onwards to domestic animals and humans.

Keywords: Arbovirus; DNA barcode; Haematophagy; Host preference; Reservoir host; Vector; Zoonosis.

MeSH terms

  • Animals
  • Arboviruses / physiology
  • Blood / parasitology*
  • Ceratopogonidae / classification*
  • Ceratopogonidae / genetics
  • Cytochromes b / genetics*
  • DNA Barcoding, Taxonomic*
  • Electron Transport Complex IV / genetics*
  • Female
  • Host Specificity
  • Humans
  • Insect Vectors / genetics
  • South Africa

Substances

  • Cytochromes b
  • Electron Transport Complex IV