Applications of the Mantel-Haenszel statistic to the comparison of survival distributions

Biometrics. 1977 Dec;33(4):617-26.

Abstract

In comparing two survival distributions, a Mantel-Haenszel statistic can be computed after each death as a non-linear two-sample rank statistic. The distributions of both the maximum and terminal statistics in such a sequence are studied numerically, in the absence of censoring, and appropriate critical values are determined. The maximum statistic is applied to simultaneous inference, and both the maximum and terminal statistics are used as the basis for early stopping procedures (especially in the pseudo-sequential context). Procedures based on the two statistics are compared for power and for early decision properties such as stopping index and (for exponential distributions) stopping time.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Biometry*
  • Clinical Trials as Topic
  • Humans
  • Mortality*
  • Time Factors