Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research

Hao Wang; Die Meng; Haoyue Guo; Chenglong Sun; Peixin Chen; Minlin Jiang; Yi Xu; Jia Yu; Qiyu Fang; Jun Zhu; Wencheng Zhao; Shengyu Wu; Sha Zhao; Wei Li; Bin Chen; Lei Wang; Yayi He

doi:10.2147/OTT.S295102

Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research

Onco Targets Ther. 2021 Mar 16:14:1895-1909. doi: 10.2147/OTT.S295102. eCollection 2021.

Authors

Hao Wang^{1

2}, Die Meng^{1

2}, Haoyue Guo^{1

2}, Chenglong Sun^{1

2}, Peixin Chen^{1

2}, Minlin Jiang^{1

2}, Yi Xu^{1

2}, Jia Yu^{1

2}, Qiyu Fang^{1

2}, Jun Zhu^{1

2}, Wencheng Zhao^{1

2}, Shengyu Wu^{1

2}, Sha Zhao¹, Wei Li¹, Bin Chen¹, Lei Wang¹, Yayi He¹

Affiliations

¹ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China.
² Tongji University, School of Medicine, Shanghai, 200433, People's Republic of China.

Abstract

Single-cell sequencing (SCS) which has an unprecedentedly high resolution is an advanced technique for cancer research. Lung cancer still has a high mortality and morbidity. For further understanding the lung cancer, SCS is also been applied to lung cancer research to investigate its heterogeneity, metastasis, drug resistance, tumor microenvironment and many other issues. In this review, we summarized lung cancer research using SCS and their research achievements.

Keywords: intratumoral heterogeneity; lung cancer; lung cancer therapy; single-cell sequencing; tumor microenvironment.

Publication types

Review

Grants and funding

This study was supported in part by a grant of Young Talents in Shanghai, National Natural Science Foundation of China (81802255), Young Talents in Shanghai (2019QNBJ), Scientific research project of Shanghai Pulmonary Hospital (fkcx1903), “Dream Tutor” Outstanding Young Talents Program (fkyq1901), Clinical Research Project of Shanghai Pulmonary Hospital (fk18005), Key Discipline in 2019 (oncology), Project of Shanghai Municipal Science and Technology Commission (Project of Municipal Science and Technology Commission), Scientific research project of Shanghai Pulmonary Hospital (fkcx1903), Shanghai Municipal Commission of Health and Family Planning (2017YQ050), Innovation Training Project of SITP of Tongji University, and Key Projects of Leading Talent (19411950300). Youth Project of Hospital Management Research Fund of Shanghai Hospital Association (Q1902037).