Kidney injury biomarkers during exposure to tenofovir-based preexposure prophylaxis

AIDS. 2021 Jun 1;35(7):1147-1149. doi: 10.1097/QAD.0000000000002865.

Abstract

We previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate (eGFR) among HIV-negative adults randomized to emtricitabine/tenofovir disoproxil fumarate preexposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case--control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between participants who subsequently experienced one of these kidney endpoints and randomly selected controls who did not.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-HIV Agents* / adverse effects
  • Biomarkers
  • Emtricitabine / adverse effects
  • HIV Infections* / drug therapy
  • HIV Infections* / prevention & control
  • Humans
  • Kidney
  • Pre-Exposure Prophylaxis*
  • Tenofovir / adverse effects

Substances

  • Anti-HIV Agents
  • Biomarkers
  • Tenofovir
  • Emtricitabine