Management of ETV6-ABL1-positive childhood acute lymphoblastic leukaemia: report of two cases, a literature review and a call for action

Br J Haematol. 2021 Apr;193(1):197-200. doi: 10.1111/bjh.17271. Epub 2021 Mar 3.
No abstract available

Keywords: ETV6-ABL1; childhood B-cell precursor acute lymphoblastic leukaemia; tyrosine kinase inhibitors.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Child, Preschool
  • Enzyme Inhibitors / therapeutic use
  • Female
  • Hematopoietic Stem Cell Transplantation / methods
  • Humans
  • In Situ Hybridization, Fluorescence / methods
  • Infant
  • Infant, Newborn
  • Karyotype
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism
  • Remission Induction
  • Transplantation, Homologous / methods
  • Treatment Outcome

Substances

  • Enzyme Inhibitors
  • Oncogene Proteins, Fusion
  • TEL-ABL fusion protein, human
  • Protein-Tyrosine Kinases