Transcriptional Biomarkers in Oral Cancer: An Integrative Analysis and the Cancer Genome Atlas Validation

Kinjal D Patel; Hemangini H Vora; Prabhudas S Patel

doi:10.31557/APJCP.2021.22.2.371

Transcriptional Biomarkers in Oral Cancer: An Integrative Analysis and the Cancer Genome Atlas Validation

Asian Pac J Cancer Prev. 2021 Feb 1;22(2):371-380. doi: 10.31557/APJCP.2021.22.2.371.

Authors

Kinjal D Patel¹, Hemangini H Vora¹, Prabhudas S Patel¹

Affiliation

¹ The Gujarat Cancer & Research Institute, Civil Hospital Campus, Asarwa, Ahmedabad-380 016, Gujarat, India.

Abstract

Objective: An impervious mortality rate in oral cancer (OC) to a certain extent explains the exigencies of precise biomarkers. Therefore, the study was intended to identify OC candidate biomarkers using samples of healthy normal tissues (N=335), adjacent normal tissues (N=93) and OC tissues (N=533) from online microarray data.

Methods: Differentially expressed genes (DEGs) were recognised through GeneSpring software (Fold change >4.0 and 'p' value.

Keywords: Biomarkers; expression profiling by array; integrative analysis; oral cancer; the cancer genome atlas.

MeSH terms

Biomarkers, Tumor / metabolism
Databases, Genetic
Gene Expression Profiling
Gene Ontology
Humans
Mouth Neoplasms / genetics*
Mouth Neoplasms / metabolism
Mouth Neoplasms / pathology
Reproducibility of Results
Transcription, Genetic / physiology

Substances

Biomarkers, Tumor