Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia

Circ Res. 2021 Apr 16;128(8):1208-1210. doi: 10.1161/CIRCRESAHA.120.318216. Epub 2021 Feb 25.
No abstract available

Keywords: doxycycline; heart failure; incidence; myocardial infarction; prolyl hydroxylase.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Mice
  • Myocardial Infarction / genetics
  • Myocardial Infarction / metabolism*
  • Myocardial Infarction / therapy
  • Procollagen-Proline Dioxygenase / metabolism*
  • RNA Interference*
  • RNAi Therapeutics / methods

Substances

  • Hif1a protein, mouse
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Procollagen-Proline Dioxygenase