A new cytotoxic compound from the leaves of Styrax annamensis Guillaumin

Nguyen Thanh Tra; Ninh The Son; Nguyen Van Tuyen; Pham Van Cuong; Nguyen Thi Thu Ha; Le Thi Tu Anh; Doan Thi Mai Huong; Truong Bich Ngan; Marc Litaudon

doi:10.1080/14786419.2021.1887868

A new cytotoxic compound from the leaves of Styrax annamensis Guillaumin

Nat Prod Res. 2022 Mar;36(6):1616-1620. doi: 10.1080/14786419.2021.1887868. Epub 2021 Feb 22.

Authors

Nguyen Thanh Tra^{1

2}, Ninh The Son¹, Nguyen Van Tuyen¹, Pham Van Cuong³, Nguyen Thi Thu Ha^{1

2}, Le Thi Tu Anh¹, Doan Thi Mai Huong³, Truong Bich Ngan³, Marc Litaudon

Affiliations

¹ Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
² Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
³ Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.

PMID: 33615920
DOI: 10.1080/14786419.2021.1887868

Abstract

New propene derivative 1-(3',4'-methylenedioxyphenyl)-2-(2''-hydroxy-5-(3'''-hydroxypropyl)-3''-methoxyphenyl)prop-2-en-1-one (1), along with three known triterpenoids ursolic acid (2), pomolic acid (3), and maslinic acid (4) were isolated from the leaves of Styrax annamensis species. All structures were assigned by spectroscopic analysis. Compound 1 showed potent cytotoxicity against four cancer cell lines (KB, HepG2, Lu, and MCF7) with the IC₅₀ values of 3.19, 2.87, 2.33, and 2.44 µM, respectively.

Keywords: Styrax annamensis; cytotoxicity; leaves; phytochemistry.

MeSH terms

Molecular Structure
Plant Leaves / chemistry
Styrax* / chemistry
Triterpenes* / chemistry

Substances

Triterpenes