Neonatal Central Nervous System Tumors

Shubin Shahab; Jason Fangusaro

doi:10.1016/j.clp.2020.11.003

Neonatal Central Nervous System Tumors

Clin Perinatol. 2021 Mar;48(1):35-51. doi: 10.1016/j.clp.2020.11.003. Epub 2021 Jan 11.

Authors

Shubin Shahab¹, Jason Fangusaro²

Affiliations

¹ Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA; Emory University School of Medicine, 1760 Haygood Drive Northeast HSRB E397, Atlanta, GA 30322, USA. Electronic address: sshahab@emory.edu.
² Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, 1405 Clifton Road Northeast, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

PMID: 33583506
DOI: 10.1016/j.clp.2020.11.003

Abstract

Central nervous system (CNS) tumors, including brain and spinal cord tumors, are the most common solid tumors of childhood. Within the neonatal population, however, CNS tumors are relatively rare. These often carry a dismal prognosis in part due to the limited therapeutic options available for newborns and the unique biology of these tumors compared with those seen in older infants and children. This article reviews neonatal CNS tumors, specifically their clinical presentation, imaging findings, treatment, prognosis, and associated genetic syndromes. The unique psychosocial and emotional challenges facing clinicians and families are discussed as well.

Keywords: Congenital CNS tumor; Congenital brain tumor; Fetal CNS tumor; Fetal brain tumor; Neonatal CNS tumor; Neonatal brain tumor.

Publication types

Review

MeSH terms

Aged
Brain
Central Nervous System Neoplasms* / diagnosis
Central Nervous System Neoplasms* / epidemiology
Central Nervous System Neoplasms* / therapy
Child
Humans
Infant
Infant, Newborn
Prognosis