The Persistence of Underreporting of Hepatitis C as an Underlying or Contributing Cause of Death, 2011-2017

Philip R Spradling; Yuna Zhong; Anne C Moorman; Loralee B Rupp; Mei Lu; Eyasu H Teshale; Mark A Schmidt; Yihe G Daida; Joseph A Boscarino; Stuart C Gordon; CHeCS Investigators

doi:10.1093/cid/ciab108

The Persistence of Underreporting of Hepatitis C as an Underlying or Contributing Cause of Death, 2011-2017

Clin Infect Dis. 2021 Sep 7;73(5):891-894. doi: 10.1093/cid/ciab108.

Authors

Collaborators

Affiliations

¹ Division of Viral Hepatitis, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
² Henry Ford Health System, Detroit, Michigan, USA.
³ The Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon, USA.
⁴ The Center for Integrated Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii, USA.
⁵ Department of Population Health Sciences, Geisinger Clinic, Danville, Pennsylvania, USA.
⁶ Wayne State University School of Medicine, Detroit, Michigan, USA.

PMID: 33561187
DOI: 10.1093/cid/ciab108

Abstract

Using electronic health records, we found that hepatitis C virus (HCV) reporting on death certificates of 2901 HCV-infected decedents from 4 US healthcare organizations during 2011-2017 was documented in only 50% of decedents with hepatocellular carcinoma and less than half with decompensated cirrhosis. National figures likely underestimate the US HCV mortality burden.

Keywords: hepatitis C; multiple cause of death; underreporting.

Published by Oxford University Press for the Infectious Diseases Society of America 2021.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Hepatocellular* / epidemiology
Cause of Death
Hepacivirus
Hepatitis C* / complications
Hepatitis C* / epidemiology
Hepatitis C, Chronic* / complications
Hepatitis C, Chronic* / epidemiology
Humans
Liver Cirrhosis / epidemiology
Liver Neoplasms*

Grants and funding

Gilead Sciences