Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance

Kun Guo; Cheng Zhao; Bin Lang; Huiqin Wang; Hang Zheng; Feng Zhang

doi:10.3389/fmolb.2020.620973

Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance

Front Mol Biosci. 2021 Jan 13:7:620973. doi: 10.3389/fmolb.2020.620973. eCollection 2020.

Authors

Kun Guo¹, Cheng Zhao¹, Bin Lang¹, Huiqin Wang¹, Hang Zheng¹, Feng Zhang¹

Affiliation

¹ College of Life Sciences, Shanghai Normal University, Shanghai, China.

Abstract

Accurate regulation of cell cycle is important for normal tissue development and homeostasis. RCC2 (Regulator of Chromosome Condensation 2) play a role as chromosomal passenger complex (CPC) implicated in all cell cycle phases. RCC2 was initially identified as Ran guanine exchange factor (GEF) for small G proteins. Therefore, RCC2 plays a key role in oncogenesis of most cancers. RCC2 is implicated in Colorectal Cancer (CRC), Lung Adenocarcinoma (LUAD), breast cancer, and ovarian cancer. Expression level of RCC2 protein determines regulation of tumor cell proliferation, invasion, metastasis, and radio-chemotherapeutic resistance. In this review, we explored proteins that interact with RCC2 to modulate tumor development and cancer therapeutic resistance by regulation of cell cycle process through various signaling pathways.

Keywords: DNA damage; cancer therapeutic resistance; chromosomal passenger complex; regulator of chromosome condensation 2; tumorgenesis.

Publication types

Review