Fertility Issues in Polycystic Ovarian Disease: A Systematic Approach

John S Rushing; Nanette Santoro

doi:10.1016/j.ecl.2020.10.004

Fertility Issues in Polycystic Ovarian Disease: A Systematic Approach

Endocrinol Metab Clin North Am. 2021 Mar;50(1):43-55. doi: 10.1016/j.ecl.2020.10.004. Epub 2021 Jan 4.

Authors

John S Rushing¹, Nanette Santoro²

Affiliations

¹ Department of Obstetrics and Gynecology, University of Colorado, 12631 East 17th Avenue Suite B198-6, Aurora, CO 80045-2529, USA.
² Department of Obstetrics and Gynecology, University of Colorado, 12631 East 17th Avenue Suite B198-1, Aurora, CO 80045-2529, USA. Electronic address: nanette.santoro@cuanschutz.edu.

PMID: 33518185
DOI: 10.1016/j.ecl.2020.10.004

Abstract

The triad of hirsutism, amenorrhea, and enlarged polycystic ovaries first was described in 1935 and later become known as polycystic ovarian syndrome (PCOS). Women with PCOS are more likely to have cardiometabolic challenges that also have an indirect relationship to their fertility and fertility outcomes. Despite these challenges, their fertile life span appears to be longer. Ovulation induction is considered first-line management of infertility in women with PCOS, with letrozole superior to clomiphene. Women with PCOS undergoing in vitro fertilization are high risk for ovarian hyperstimulation syndrome but also have a higher live birth rate compared with controls.

Keywords: Fertility; IVF; OHSS; Ovulation induction; PCOS.

Publication types

Review

MeSH terms

Clomiphene
Female
Fertility
Fertility Agents, Female
Humans
Infertility, Female* / etiology
Polycystic Ovary Syndrome* / complications

Substances

Fertility Agents, Female
Clomiphene