Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins

Circ Res. 2021 Mar 19;128(6):738-751. doi: 10.1161/CIRCRESAHA.120.317715. Epub 2021 Jan 27.

Abstract

[Figure: see text].

Keywords: aldo-keto reductases; coronary circulation; ion channels; physiology; potassium channels.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Cells, Cultured
  • Coronary Circulation*
  • Kv1.3 Potassium Channel / genetics
  • Kv1.3 Potassium Channel / metabolism*
  • Lactic Acid
  • Mice
  • Mice, Inbred C57BL
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / metabolism*
  • Muscle, Smooth, Vascular / physiology
  • Myocardial Contraction
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / physiology
  • Myocytes, Smooth Muscle / metabolism
  • Oxygen / metabolism*
  • Shaker Superfamily of Potassium Channels / genetics
  • Shaker Superfamily of Potassium Channels / metabolism*
  • Vasoconstriction
  • Vasodilation

Substances

  • Kcnab1 protein, mouse
  • Kcnab2 protein, mouse
  • Kv1.3 Potassium Channel
  • Shaker Superfamily of Potassium Channels
  • Lactic Acid
  • Oxygen