Validity and reliability of Patient-Reported Outcomes Measurement Information System Global Health scale in adults with atopic dermatitis

Gabrielle Schwartzman; Donald Lei; Muhammad Yousaf; Sherief R Janmohamed; Paras P Vakharia; Rishi Chopra; Rajeev Chavda; Sylvie Gabriel; Kevin R Patel; Vivek Singam; Robert Kantor; Derek Y Hsu; Jonathan I Silverberg

doi:10.1016/j.jaad.2021.01.033

Validity and reliability of Patient-Reported Outcomes Measurement Information System Global Health scale in adults with atopic dermatitis

J Am Acad Dermatol. 2021 Sep;85(3):636-644. doi: 10.1016/j.jaad.2021.01.033. Epub 2021 Jan 20.

Authors

Affiliations

¹ Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
² Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.
³ Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
⁴ State University of New York Downstate Medical Center, Brooklyn, New York.
⁵ Galderma SA, Rx Strategy and Innovation Group, La Tour-de-Peliz, Switzerland.
⁶ Department of Dermatology, Dell Medical School, University of Texas, Austin, Texas.
⁷ Department of Internal Medicine, Weiss Memorial Hospital, Chicago, Illinois.
⁸ Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁹ Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois. Electronic address: jonathanisilverberg@gmail.com.

PMID: 33484762
DOI: 10.1016/j.jaad.2021.01.033

Abstract

Background: Patient-Reported Outcomes Measurement Information System Global Health (PGH) was validated to assess health-related quality of life in several diseases. Little is known about its measurement properties in adult atopic dermatitis.

Objective: Examine the measurement properties of PGH in adult atopic dermatitis.

Methods: A prospective dermatology practice-based study of 994 atopic dermatitis patients (18-97 years).

Results: PGH physical and mental health 4-item and abridged 2-item T scores, as well as mapped EuroQol-5D score, showed strong to very strong correlation with one another and moderate to strong Spearman correlations with Patient-Oriented Scoring Atopic Dermatitis, Patient-Health Questionnaire-9, Patient-Reported Outcomes Measurement Information System sleep disturbance and related impairment, Eczema Area and Severity Index, objective Scoring Atopic Dermatitis; and weak to moderate correlations with Patient Oriented Eczema Measure, numeric rating scale worst itch and average itch, and Scoring Atopic Dermatitis. The Dermatology Life Quality Index (DLQI) had stronger correlations with Patient Oriented Eczema Measure, Patient-Oriented Scoring Atopic Dermatitis, numeric rating scale worst itch and average itch, Eczema Area and Severity Index, and Scoring Atopic Dermatitis, but weaker correlations with Patient-Health Questionnaire-9 and Patient-Reported Outcomes Measurement Information System sleep disturbance and related impairment (convergent/divergent validity). PGH and DLQI scores had similarly poor ability to differentiate between levels of self-reported global atopic dermatitis severity (known-groups validity). No floor or ceiling effects were observed. No PGH or DLQI items had differential item functioning by demographics. PGH and DLQI scores showed fair to good responsiveness. Finally, PGH and DLQI showed similarly good test-retest reliability.

Limitations: Single-center study.

Conclusion: PGH scores had sufficient validity and reliability to assess health-related quality of life in atopic dermatitis.

Keywords: atopic dermatitis; eczema; itch; patient-reported outcomes; pruritus; severity.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Dermatitis, Atopic* / diagnosis
Dermatitis, Atopic* / epidemiology
Eczema*
Global Health
Humans
Information Systems
Middle Aged
Patient Reported Outcome Measures
Prospective Studies
Pruritus
Quality of Life
Reproducibility of Results
Severity of Illness Index
Sleep Wake Disorders / diagnosis
Sleep Wake Disorders / epidemiology
Sleep Wake Disorders / etiology
Young Adult