1 Department of Critical Care Medicine, University Hospitals Birmingham National Health Service Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK; Birmingham Acute Care Research, Institute of Inflammation and Ageing, Centre of Translational Inflammation Research, University of Birmingham, Birmingham, UK.
2 Department of Cardiac Anesthesia and Intensive Care, University Hospitals Leicester National Health Service Trust, Glenfield Hospital, Leicester, UK.
3 Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada.