A Systematic Review on the Association between Lipid Accumulation Product Index and Type 2 Diabetes Mellitus

Gratcia Ayundini; Cindy Astrella; Dicky Tahapary; Pradana Soewondo

doi:10.15605/jafes.034.01.04

A Systematic Review on the Association between Lipid Accumulation Product Index and Type 2 Diabetes Mellitus

J ASEAN Fed Endocr Soc. 2019;34(1):16-20. doi: 10.15605/jafes.034.01.04. Epub 2019 May 28.

Authors

Gratcia Ayundini¹, Cindy Astrella², Dicky Tahapary^{2

3}, Pradana Soewondo^{2

3}

Affiliations

¹ Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia.
² Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia.
³ Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia.

Abstract

Introduction: Excess fat accumulation contributes to the development of type 2 diabetes mellitus (T2DM). Lipid accumulation product (LAP) is an index computed from waist circumference and triglycerides, which represents increased lipotoxicity. We aim to study the relationship of LAP index and T2DM and its utility as a predictor for T2DM development.

Methodology: A literature search in PubMed and Cochrane database was performed to retrieve and review studies reporting the association between LAP and T2DM.

Results: Two cross-sectional studies from Japan and the United States, and one cohort study from Iran were obtained. A high LAP was associated with a higher risk of T2DM [odds ratio (OR) 19.1, 95% confidence interval (CI) (6.6-55.5) for women; and OR 7.4, 95% CI (5.1-10.8) for men].

Conclusion: LAP was strongly associated with T2DM. Its utility in predicting the development of T2DM needs to be confirmed.

Keywords: insulin resistance; lipid accumulation product; obesity; type 2 diabetes mellitus.

Publication types

Review