Coffee Intake and Colorectal Cancer Incidence According to T-Cell Response

Tomotaka Ugai; Koichiro Haruki; Juha P Väyrynen; Rong Zhong; Jennifer Borowsky; Kenji Fujiyoshi; Mai Chan Lau; Melissa Zhao; Naohiko Akimoto; Tzuu-Wang Chang; Junko Kishikawa; Kota Arima; Shan-Shan Shi; Simeng Gu; Charles S Fuchs; Edward L Giovannucci; Marios Giannakis; Xuehong Zhang; Mingyang Song; Jeffrey A Meyerhardt; Molin Wang; Jonathan A Nowak; Shuji Ogino

doi:10.1093/jncics/pkaa068

Coffee Intake and Colorectal Cancer Incidence According to T-Cell Response

JNCI Cancer Spectr. 2020 Sep 7;4(6):pkaa068. doi: 10.1093/jncics/pkaa068. eCollection 2020 Dec.

Authors

Tomotaka Ugai^{1

2}, Koichiro Haruki¹, Juha P Väyrynen^{1

3}, Rong Zhong¹, Jennifer Borowsky⁴, Kenji Fujiyoshi¹, Mai Chan Lau¹, Melissa Zhao¹, Naohiko Akimoto¹, Tzuu-Wang Chang¹, Junko Kishikawa¹, Kota Arima¹, Shan-Shan Shi¹, Simeng Gu¹, Charles S Fuchs^{5

6

7}, Edward L Giovannucci^{2

8

9}, Marios Giannakis^{3

10

11}, Xuehong Zhang^{8

9}, Mingyang Song^{8

12

13}, Jeffrey A Meyerhardt³, Molin Wang^{2

9

14}, Jonathan A Nowak¹, Shuji Ogino^{1

2

10

15}

Affiliations

¹ Department of Pathology, Brigham and Women's Hospital, Program in MPE Molecular Pathological Epidemiology, Harvard Medical School, Boston, MA, USA.
² Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
³ Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
⁴ Conjoint Gastroenterology Department, QIMR Berghofer Medical Research Institute, Queensland, Brisbane, Australia.
⁵ Yale Cancer Center, New Haven, CT, USA.
⁶ Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
⁷ Smilow Cancer Hospital, New Haven, CT, USA.
⁸ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁹ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁰ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹¹ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹² Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
¹³ Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
¹⁴ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
¹⁵ Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, MA, USA.

Abstract

We hypothesized that the associations between coffee intake and colorectal cancer (CRC) incidence might differ by immune cell densities in CRC tissue. Using the Nurses' Health Study and the Health Professionals Follow-up Study, we examined the association of coffee intake with incidence of CRC classified by intraepithelial or stromal T-cell subset densities by multiplex immunofluorescence assay for CD3, CD4, CD8, CD45RO (PTPRC), and FOXP3. We applied an inverse probability-weighted Cox proportional hazardsregression model to control for selection bias and potential confounders. During follow-up of 133 924 participants (3 585 019 person-years), we documented 3161 incident CRC cases, including 908 CRC cases with available data on T-cell densities in tumor tissue. The association between coffee intake and CRC was not statistically significantly different by intraepithelial or stroma T-cell subset (P _{heterogeneity} > .38). Hence, there is no sufficient evidence for differential effect of coffee intake on incidence of CRC subtypes classified by T-cell infiltrates.