ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

Nicole Concin; Xavier Matias-Guiu; Ignace Vergote; David Cibula; Mansoor Raza Mirza; Simone Marnitz; Jonathan Ledermann; Tjalling Bosse; Cyrus Chargari; Anna Fagotti; Christina Fotopoulou; Antonio Gonzalez Martin; Sigurd Lax; Domenica Lorusso; Christian Marth; Philippe Morice; Remi A Nout; Dearbhaile O'Donnell; Denis Querleu; Maria Rosaria Raspollini; Jalid Sehouli; Alina Sturdza; Alexandra Taylor; Anneke Westermann; Pauline Wimberger; Nicoletta Colombo; François Planchamp; Carien L Creutzberg

doi:10.1136/ijgc-2020-002230

ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

Int J Gynecol Cancer. 2021 Jan;31(1):12-39. doi: 10.1136/ijgc-2020-002230. Epub 2020 Dec 18.

Authors

Nicole Concin^{1

2}, Xavier Matias-Guiu^{3

4}, Ignace Vergote⁵, David Cibula⁶, Mansoor Raza Mirza⁷, Simone Marnitz⁸, Jonathan Ledermann⁹, Tjalling Bosse¹⁰, Cyrus Chargari¹¹, Anna Fagotti¹², Christina Fotopoulou¹³, Antonio Gonzalez Martin¹⁴, Sigurd Lax^{15

16}, Domenica Lorusso¹², Christian Marth¹⁷, Philippe Morice¹⁸, Remi A Nout¹⁹, Dearbhaile O'Donnell²⁰, Denis Querleu^{12

21}, Maria Rosaria Raspollini²², Jalid Sehouli²³, Alina Sturdza²⁴, Alexandra Taylor²⁵, Anneke Westermann²⁶, Pauline Wimberger²⁷, Nicoletta Colombo²⁸, François Planchamp²⁹, Carien L Creutzberg³⁰

Affiliations

¹ Department of Gynecology and Obstetrics, Innsbruck Medical University, Innsbruck, Austria nicole.concin@i-med.ac.at.
² Evangelische Kliniken Essen-Mitte, Essen, Germany.
³ Department of Pathology, Hospital Universitari Arnau de Vilanova, University of Lleida, CIBERONC, Irblleida, Spain.
⁴ Department of Pathology, Hospital Universitari de Bellvitge, University of Barcelona, Idibell, Spain.
⁵ Department of Gynecology and Obstetrics, Gynecologic Oncology, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium.
⁶ Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University, General University Hospital in Prague, Prague, Czech Republic.
⁷ Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
⁸ Department of Radiation Oncology, Medical Faculty of the University of Cologne, Cologne, Germany.
⁹ UCL Cancer Institute, University College, London, UK.
¹⁰ Department of Pathology, Leids Universitair Medisch Centrum, Leiden, Netherlands.
¹¹ Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France.
¹² Division of Gynecologic Oncology, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
¹³ Department of Gynaecologic Oncology, Imperial College London Faculty of Medicine, London, UK.
¹⁴ Department of Medical Oncology, Clinica Universidad de Navarra, Madrid, Spain.
¹⁵ Department of Pathology, Hospital Graz II, Graz, Austria.
¹⁶ School of Medicine, Johannes Kepler University Linz, Linz, Austria.
¹⁷ Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria.
¹⁸ Department of Surgery, Institut Gustave Roussy, Villejuif, France.
¹⁹ Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
²⁰ Department of Medical Oncology, St James Hospital, Dublin, Ireland.
²¹ Department of Obstetrics and Gynecologic Oncology, University Hospital, Strasbourg, France.
²² Histopathology and Molecular Diagnostics, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
²³ Department of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
²⁴ Department of Radiation Oncology, Comprehensive Cancer Center, Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.
²⁵ Department of Gynaecology, Royal Marsden Hospital, London, UK.
²⁶ Department of Medical Oncology, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, Netherlands.
²⁷ Department of Gynecology and Obstetrics, TU Dresden Medizinische Fakultat Carl Gustav Carus, Dresden, Germany.
²⁸ Gynecologic Oncology Program, European Institute of Oncology, IRCCS, Milan and University of Milan-Bicocca, Milan, Italy.
²⁹ Clinical Research Unit, Institut Bergonie, Bordeaux, France.
³⁰ Department of Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands.

PMID: 33397713
DOI: 10.1136/ijgc-2020-002230

Abstract

A European consensus conference on endometrial carcinoma was held in 2014 to produce multi-disciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly decided to update these evidence-based guidelines and to cover new topics in order to improve the quality of care for women with endometrial carcinoma across Europe and worldwide.

Keywords: pathology; radiation; surgery; uterine cancer.

Publication types

Practice Guideline
Research Support, Non-U.S. Gov't

MeSH terms

Endometrial Neoplasms / diagnosis*
Endometrial Neoplasms / pathology
Endometrial Neoplasms / therapy*
Europe
Female
Genital Neoplasms, Female / diagnosis*
Genital Neoplasms, Female / therapy*
Humans
Medical Oncology / standards*
Preoperative Care
Risk Factors