The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker

Xuewen Tan; Haifeng Jiang; Yilong Fang; Dafei Han; Yawei Guo; Xinming Wang; Xun Gong; Wenming Hong; Jiajie Tu; Wei Wei

doi:10.7150/jca.49203

The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker

J Cancer. 2021 Jan 1;12(1):224-231. doi: 10.7150/jca.49203. eCollection 2021.

Authors

Xuewen Tan¹, Haifeng Jiang¹, Yilong Fang¹, Dafei Han¹, Yawei Guo¹, Xinming Wang², Xun Gong¹, Wenming Hong², Jiajie Tu¹, Wei Wei¹

Affiliations

¹ Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, China.
² The First Affiliated Hospital of Anhui Medical University.

Abstract

Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation.

Keywords: GAS5; chemosensitivity; glioma; miRNA.

Publication types

Review