Non invasive in vivo monitoring of dimethyl fumarate treatment in EAE by assessing the glucose metabolism in secondary lymphoid organs

Eur J Immunol. 2021 Apr;51(4):1006-1009. doi: 10.1002/eji.202048879. Epub 2020 Dec 28.

Abstract

[18 F]FDG-PET/CT is a high sensitive functional diagnostic imaging modality to monitor tumor but also immune cell activation by determination of the glucose metabolism. Our results show that the anti-inflammatory effects of immunotherapeutics like DMF can be assessed non invasively in vivo during Th1/Th17 cell-mediated encephalomyelitis (EAE) by [18 F]FDG-PET/CT imaging of the draining lymph nodes.

Keywords: Dimethyl fumarate; EAE; T cell vaccine; [18F]FDG-PET/CT; glucose metabolism.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dimethyl Fumarate / immunology*
  • Dimethyl Fumarate / therapeutic use
  • Drug Monitoring / methods*
  • Encephalomyelitis, Autoimmune, Experimental / diagnostic imaging
  • Encephalomyelitis, Autoimmune, Experimental / drug therapy
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Fluorodeoxyglucose F18 / metabolism
  • Glucose / metabolism*
  • Humans
  • Lymph Nodes / drug effects
  • Lymph Nodes / immunology*
  • Lymph Nodes / metabolism
  • Mice
  • Positron Emission Tomography Computed Tomography / methods*
  • Th1 Cells / drug effects
  • Th1 Cells / immunology
  • Th1 Cells / metabolism
  • Th17 Cells / drug effects
  • Th17 Cells / immunology
  • Th17 Cells / metabolism

Substances

  • Fluorodeoxyglucose F18
  • Dimethyl Fumarate
  • Glucose