Challenges in measuring renal function in liver cirrhosis: are there implications in clinical practice?

J Carvão; J N Carvão; V Pereira; L Jasmins

Challenges in measuring renal function in liver cirrhosis: are there implications in clinical practice?

Acta Gastroenterol Belg. 2020 Oct-Dec;83(4):633-638.

Authors

J Carvão¹, J N Carvão², V Pereira¹, L Jasmins¹

Affiliations

¹ Gastroenterology Department, Hospital Central do Funchal, Madeira Island, Portugal.
² Nephrology Department, Hospital Central do Funchal, Madeira Island, Portugal.

PMID: 33321021

Abstract

Renal dysfunction is frequent in liver cirrhosis, and it is associated with poor prognosis. Currently, there are major limitations when assessing renal function in cirrhotic patients. Available methods are biased and have a tendency to overestimate glomerular filtration rates (GFR) consistently. A subset of new creatinine-based formulas derived specifically from these populations may provide a more accurate estimation of renal function. In this article, we will explore the estimation methods of GFR in cirrhosis available to date and discuss possible implications in clinical practice.

Keywords: kidney; liver cirrhosis; liver transplant.

Publication types

Review

MeSH terms

Creatinine
Glomerular Filtration Rate
Humans
Liver Cirrhosis* / complications
Liver Cirrhosis* / diagnosis

Substances

Creatinine